Prof. Dr. med. Andreas Gaumann

Facharzt

Curriculum Vitae

Studium

1990 – 1996

Studium Humanmedizin, Johannes Gutenberg Universität, Mainz

1996 – 2000

Institut für Pathologie Universität Mainz (Prof. Dr. C.J. Kirkpatrick)

Beruflicher Werdegang

2000 – 2001

Allgemein- und Abdominalchirurgie Universität Mainz (Prof. Dr. T. Junginger)

2001 – 2003

Max-Planck-Institut für Physiologische und Klinische Forschung (Molecular Cell Biology of the vessels Prof. G. Breier PhD)

seit 2003

Institut für Pathologie Universität Regensburg (Prof. F. Hofstädter)

03. – 04. 2006

Forschungsaufenthalt am Armed Forces Institute of Pathology (AFIP). Washington D.C.

10. 2006

Facharzt für Pathologie (BLÄK)

2007 – 2008

Oberarzt im Institut für Pathologie der Universität Regensburg

12. 2008

Habilitation zum Dr. med. habil. im Fach Pathologie der Universität Regensburg
Thema: „Antiangiogenese: Tumortherapie des 21. Jahrhunderts: Morphometrische Analysen als Basis für die Tumortherapie“

seit 2009

Institut für Pathologie Kaufbeuren

06. 2009

Verleihung der „Venia legendi“ im Fach Pathologie durch das Bayerische Ministerium für Wissenschaft und Forschung in München

11. 2017

Bestellung zum „außerplanmäßigen Professor“ an der Fakultät der Universität Regensburg

Niederlassung

seit 01.04.2009

Als Pathologe in der BAG Institut für Pathologie Kaufbeuren

Mitgliedschaften

  • Deutsche Gesellschaft für Pathologie (DGP)
  • Deutsche Sektion der Internationalen Akademie für Pathologie (IAP)
  • European Society of Pathology (ESP)
  • Pathological Society of Great Britain and Ireland
  • American Society for Investigative Pathology
  • American Association for the Advancement of Science (AAAS)
  • Max-Planck-Gesellschaft e.V.
  • Deutsche Krebsgesellschaft e.V.
  • Bundesverband Deutscher Pathologen e.V. (BVDP)

Wissenschaft

Entwicklungsbiologie, Physiologie und Pathologie der Angiogenese,
Tumor – Angiogenese in Experimentaltumoren and humanen primären Tumoren.
Therapeutische Anwendung von Rezeptortyrosinekinaseinhibitoren in experimentellen Modellen und am Patienten. Apoptose, Invasion und Chemoresistenz in Sarkomen and Karzinomen, Molekulare Diagnostik

Publikationen

* gekennzeichnete Veröffentlichungen für kumulative Habilitationsarbeit

[1] Gaumann A, Hoeckel M, Konerding MA:
The anatomical basis of the transversus and rectus abdominis musculoperitoneal (TRAMP) composite flap
Hernia, 1999; (3):39 – 41
nicht im Index gelistet

[2] Gaumann A, Laudes M, Jacob B, Pommersheim R, Laue C, Vogt W, Schrezenmeir J:
Effect of media composition on long term in vitro stability of barium-alginate and polyacrylic acid multilayer microcapsules
Biomaterials, 2000; 21(18):1911 – 1917
IF: 1.796

[3] Tews DS, Nissen A, Külgen C, Gaumann A:
Drug resistance-associated factors in primary and secondary glioblastomas and their precursor tumors.
J Neurooncol, 2000;50(3):227 – 237
IF: 1.581

[4] Gaumann A, Laudes M, Jacob B, Pommersheim R, Laue C, Vogt W, Schrezenmeir J:
Xenotransplantation of pararthyroids in rats using barium-alginate and polyacrylic acid multilayer microcapsules
Exp Toxicol Pathol, 2001;53(1):35-43
IF: 0.636

*[5] Konerding MA, Fait E, Gaumann A:
3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon
Brit J Cancer, 2001;84(10):1354 – 1362
IF: 3.942

[6] Tews DS, Fleissner C, Tiziani B, Gaumann A:
Intrinsic expression of drug resistance-associated factors in meningeomas
Appl Immunohistochem & Mol Morphol, 2001;9(3):242 – 249
IF: 0.989

[7] Gaumann A, Tews DS, Mayer E, Dahm M, Petrow PK, Otto M, Kirkpatrick CJ, Kriegsmann J:
Expression of apoptosis-related proteins, p53, and DNA-fragmentation in sarcomas of the pulmonary artery.
Cancer, 2001; 92(5):1237 – 1244
IF: 3.99

[8] Gaumann A, Petrow PK, Mentzel T, Mayer E, Dahm M, Otto M, Kirkpatrick CJ, Kriegsmann J:
Osteopontin expression in primary sarcomas of the pulmonary artery
Virchows Archiv, 2001;439(5):668 – 674
IF: 1.79

[9] Gaumann A, Tews DS, Mentzel T, Petrow PK, Mayer E, Otto M, Kirkpatrick CJ, Kriegsmann J.
Expression of drug resistance related proteins in sarcomas of the pulmonary artery and poorly differentiated leiomyosarcomas of other origin.
Virchows Archiv 2003; 442(6):529 – 537
IF: 1.64

*[10] Gaumann A, Koehl GE, Zuelke C, Hoehn A, Hofstädter F, Schlitt HJ, Geissler EK
Development of de novo cancer in p53 knock-out mice is dependent on the type of long-term immunosupression used
* equal contribution
Transplantation 2006;82(6): 741-8
IF: 3.87

*[11] Gaumann A, Schmid S, Schulte S, Mueller-Klieser W, Wheatley D, Kunz-Schughart L
Lactate adversly affects the in vitro formation of endothelial cell tubular structures through the action of TGF-1
* equal contribution
Exp Cell Res; 2007;313 (12):2531-49
IF: 4.148

*[12] Gaumann A, Schermutzki G, Mentzel T, Kirkpatrick CJ, Kriegsmann J, Konerding MA
Microvessel density and VEGF/VEGF receptor status and their role in sarcomas of the pulmonary artery
Oncol Rep; 2008;19(2):309-18.
IF: 1.572

*[13] I Gaumann A, Schlitt HJ, Geissler EK
Immunosupression and tumor development in organ transplant recipients: The emerging dualistic role of Rapamycin
Transpl Int; 2008;21(3):207-1
IF: 1.797

*[14] Gaumann A, Strubel G, Bode-Lesniewska B, Schmidtmann I, Kriegsmann, Kirkpatrick CJ
The signficance of tumor vascularisation in benign and malignant cardiovascular neoplasms. A comparison of cardiac myxoma and sarcomas of the pulmonary artery
Oncol Rep, im Druck
IF: 1.572

[15] Gaumann A, Bode-Lesniewska B, Zimmermann DR, Fanburg-Smith JC, Kirkpatrick CJ, Hofstädter F, Woenckhaus M, Stoehr R, Dietmaier W, Hartmann A
The role of the APC/ß-catenin Pathway pulmonary artery sarcomas
Virchows Archiv: eingereicht
IF: 3.426

[16] Konerding MA, Gaumann A, Shumsky A, Schlenger K, Hoeckel M:
The vascular anatomy of the inner anterior abdominal wall with special reference to the transversus and rectus abdominis musculoperitoneal (TRAMP) composite flap for vaginal reconstruction.
Plast Reconstr Surg, 1997;99(3):705 – 710
IF: 1.439

[17] Konerding MA, Dzemali O, Gaumann A, Malkusch W, Eckhardt VF:
Correlation of endoanal sonography with cross-sectional anatomy of the anal sphincter.
Gastrointest Endosc, 1999; 50(6):804 – 810
IF: 3.225

[18] Hansen T, Petrow PK, Gaumann A, Keyszer GM, Eysel P, Eckardt A, Bräuer R, Kriegsmann J:
Cathepsin B and its endogenous inhibitor Cystatin C in rheumatoid arthritis synovium
J Rheumatol 2000; 27(4):859 – 865
IF: 2.91

[19] Kriegsmann J, Müller H, Sommer M, Stiller K, Bräuer R, Petrow PK, Gaumann A, Fünfstück RD, Stein G:
Expression of LFA-1(CD11a/CD18) and ICAM-1 (CD54) in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction
Exp Toxic Pathol, 2000; 52(3):185 – 191
IF: 0.689

[20] Hansen T, Petrow PK, Gaumann A, Keyszer GM, Bräuer R, Kriegsmann J:
Synovial giant cells in rheumatoid arthritis: Expression of cystatin C, but not of cathepsin B
Exp Toxic Pathol, 2000; 52(4):312 – 316
IF: 0.689

[21] Hansen T, Otto M, Eckardt A, Gaumann A, Kirkpatrick CJ, Kriegsmann J:
Große Polyethylenabriebpartikel in gelockerten Hüftendoprothesen. Histomorphometrische und immunhistologische Untersuchungen
Osteologie, 2000;6(3):195 – 199
Nicht im Index gelistet

[22] Mayer E, Kriegsmann J, Gaumann A, Kauczor HU, Dahm M, Hake U, Schmid FX, Oelert H:
Surgical treatment of pulmonary artery sarcoma
J Thoracic Cardiovasc Surg, 2001;121(1):77 – 82
IF: 3.057

[23] Kramm T, Gaumann A, Heussel CP, Dahm M, Oelert H, Mayer E:
Surgical management of pulmonary artery sarcoma
Deutsche Medizinische Wochenschrift, 2001;126(50):1423 – 1427
IF: 0.74

[24] Laudes M, Gaumann A, Laue C, Schrezenmeir J:
Improved yield and functionality of parathyroid cells separated by using a collagenase-digestion with cold preincubation
J Endocrinol Invest, 2001;24(2):98-103
IF: 1.592

[25] Hansen T, Petrow PK, Gaumann A, Keyszer GM, Otto M, Kirkpatrick CJ, Kriegsmann J:
Expression of cysteine proteinases cathepsin B and K and of the cysteine proteinase inhibitor Cystatin C in giant cell tumors of the tendon sheet
Modern Pathol, 2001;14(4): 318 – 324
IF: 3.211

[26] Hansen T, Otto M, Gaumann A, Eckardt A, Petrow PK, Kirkpatrick CJ, Kriegsmann J:
Cathepsin K in aseptic hip prosthesis loosening: expression in osteoclasts without poylethylene wear particles.
J Rheumatol, 2001;28(7):1615 – 1619
IF: 2.591

[27] Hansen T, Unger R, Gaumann A, Hundorf I, Maurer J, Kriegsmann J:
The expression of matrix – degrading cysteine proteinase cathepsin K in cholesteatomas
Modern Pathology, 2001; 14(12):1226 – 1231
IF: 3.211

*[28] Vajkoczy P, Farhadi M, Gaumann A, Heidenreich R, Erber R, Wunder A, Tonn JC, Menger MD, Breier G
Microtumor growth initiates aniogenic sprouting with simultaneous expression of VEGF, VEGF receptor – 2 and angiopoietin – 2JCI2002
J Clin Invest, 2002; 109:777-785
IF: 14.05

[29] Brockmann H, Schwarting A, Kriegsmann J Petrow P, Gaumann A, Müller KM, Galle PR, Mayet W
Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener’s granulomatosis
Arthritis Res; 2002; (4):220-225
IF: 3.436

[30] Hansen T, Otto M, Buchorn G, Scharnweber D, Gaumann A, Delank S, Eckardt A, Willert HG, Kriegsmann C, Kirkpatrick CJ
New aspects in the morphological detection of wear particles in failed total joint replacements
Acta Histochemica, 2002; 104(3):263-269
IF: 0,867

[31] Hilbers I, Hansen T, Petrow PK, Gaumann A, Bräuer R, Salzmann G, Gay RE, Kosmehl H, Krikpatrick CJ, Gay S, Kriegsmann J:
Expression of the apoptosis accelerator Bax in rheumatoid arthritis synovium.
Rheumatol Int. 2003 Mar;23(2):75-81
IF: 1.04

[32] Issbrücker K, Marti HH, Hippenstiel S, Springmann G, Vosswinckel R, Gaumann A, Breier G, Drexler HC, Suttorp N, Clauss M
p38 MAPK – a molecular switch between VEGF-induced angiogenesis and vascular permeability
FASEB J. 2003; 17(2):262 – 264
IF: 12.74

[33] Voswinckel R, Ziegelhoeffer T, Heil M, Kostin S, Breier G, Mehling T, Haberberger R, Clauss M, Gaumann A, Schaper W, Seeger W
Circulating vacular progenitor cells do not contribute to compensatory lung growth
Circ Res, 2003; 93 (4): 372 – 379
IF:6.06

[34] Raab S, Beck H, Gaumann A, Yuce A, Gerber HP, Plate K, Hammes HP, Ferrara N, Breier G.
Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor.
Thromb Haemost. 2004; 91(3):595 – 605.
IF: 3.413

[35] Wolloschek T, Gaumann A, Terzic A, Heintz A, Junginger T, Konerding MA
Inguinal hernia: Measurement of the biomechanics of the lower abdominal wall and the inguinal canal
Hernia 2004
Nicht im Index gelistet

[36] Ho JC, Konerding MA, Gaumann A, Groth M, Liu KWK
Fungal polysaccharopeptide inhibits angiogenesis and tumor growth in mice
Life Sci 2004;75(11):1343-56
IF: 2.158

[37] Agaimy A, Wünsch HP, Hofstaedter F, Blaszyk H, Rümmele P, Gaumann A, W. Dietmaier W, Hartmann A
Minute Gastric Sclerosing Stromal Tumors (GIST Tumorlets) Are Common in Adults And Show Frequently C-KIT Mutations
Am J Surg Pathol 2007;31(1): 113-120
IF: 4.377

*[38] Lang S, Gaumann A, Koehl G, Bataille F, Klein D, Ellis LM, Bolder U, Hofstädter F, Schlitt HJ, Geissler EK, Stöltzing O
Mammalian Targe of Rapamycin (mTOR) is activated in human gastric cancer and serves as a target for therapy in an experimental murine tumor model
Int J Cancer 2007; 120(8): 1803-1810
IF: 4.7

[Intraepithelial neoplasms (PanIN) and intraductal papillary-mucinous neoplasms (IPMN) of the pancreas as precursor lesions of pancreatic carcinoma]
Ott C, Heinmöller E, Gaumann A, Schölmerich J, Klebl F.
Med Klin (Munich). 2007 Feb 15;102(2):127-35

*[39] Lang SA, Klein D, Moser C, Gaumann A, Glockzin G, Dahlke MH, Dietmaier W, Bolder U, Schlitt HJ, Geissler EK, Stoeltzing O
Inhibition of heat-shock protein 90 impairs EGF- mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo
Mol Cancer Ther; 2007; 6(3):1123-1132
IF: 5.171

[40] Hashimoto A, Tarner IH, Bohle RM, Gaumann A, Manetti M, Distler O, Steinmeyer J, Ulfgren A-K, Schulz A, Gay S, Müller-Ladner U, Neumann E
Analysis of vascular gene expression in arthritic synovium by laser-mediated
Microdissection
Arthritis&Rheumatism; 2007; 56(4):1094-1105
IF: 7.421

[41] Lang SA, Moser C, Gaumann A, Klein D, Glockzin G, Popp FC, Dahlke MH, Piso P, Schlitt HJ, Geissler EK, Stoeltzing O
Targeting Hsp90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an IL-6/STAT3/HIF-1 autocrine loop, and reduces orthotopic tumor growth
Clin Cancer Res; 2007, 13(21):6459-68
IF: 5.715

[42] Agaimy A, Gaumann A, Schroeder J, Dietmaier W, Hartmann A, Hofstädter F, Wünsch PH, Mentzel T
Primary and metastatic high-grade pleomorphic sarcoma/malignant fibrous histiocytoma of the gastrointestinal tract: an approach to the differential diagnosis in a series of five cases with emphasis on myofibroblastic differentiation.
Virchows Arch 2007, 451(5):949-57
IF:2.251

[43] Agaimy A, Wunsch PH, Schroeder J, Gaumann A, Dietmaier W, Hartmann A, Hofstaedter F, Mentzel T.
Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma).
J Clin Pathol 2007, May 18th (EPub ahead of print)
IF: 2.17

[44] Woenckhaus M, Merk J, Stoehr R, Schaeper F, Gaumann A, Wiebe K, Hartmann A, Hofstaedter F, Dietmaier, W
Prognostic Value of FHIT, CTNNB1 and MUC1 Expression in Non-Small Cell Lung Cancer
Hum Pathol. 2008, 39(1):126-36
IF: 2.55

[45] Moser C, Lang S, Gaumann A, Schlitt HJ, Geissler EK, Stöltzing O
Blocking Hsp90 inhibits invasive properties and hepatic growth of human
colon cancer cells and improves efficacy of oxaliplatin in p53-deficient
colon cancer tumors in vivo
Mol Cancer Ther. 2007;6(11):2868-78
IF: 5.171

[46] Agaimy A, Gaumann A, Wünsch PH, Hofstaedter F, Blaszyk H, Rümmele P, Hartmann A, Dietmaier W.
A subset of spindle cell KIT-positive and epithelioid KIT-negative gastric stromal tumors arise from a common KIT expressing precursor lesion (sclerosing stromal tumorlets).
J Clin Pathol: eingereicht
IF: 2.245

[47] Ahlbrecht K, Schmitz J, Schwarz C, Seay U, Mitnacht-Kraus R, Gaumann A, Haberberger RV, Herold S, Breier G, Grimminger F, Seeger W, Voswinckel R
Expression and functionality of VEGFR-2 in pulmonary epithelial cells during lung
development
American Journal of Respiratory Cell and Molecular Biology,
IF:3.998

[48] Gluz O, Wild P, Meiler R, Diallo-Danebrock R, Ting E, Mohrmann S, Schuett G, Dahl E, Fuchs T, Herr A, Gaumann A, Frick M, Poremba C, Nitz UA, Hartmann A
Nuclear Karyopherin 2 expression predicts poor survival in patients with advanced breast cancer irrespective of treatment intensity.
Int J Cancer, akzeptiert
IF: 4.7

[49] Moser C, Schachtschneider P, Lang SA, Gaumann A, Mori A, Zimmermann J, Schlitt HJ, Geissler EK
Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis
European Journal of Cancer, im Druck
IF: 3,706

[50] Ganzer R, Blana A, Gaumann A, Stolzenburg JU, Rabenalt R, Bach T, Wieland W, Denzinger S
Topographical Anatomy of periprostatic and capsular nerves: quantification and computerised planimetry
European Urology, im Druck
IF: 4,83

Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes.
Lang SA, Schachtschneider P, Moser C, Mori A, Hackl C, Gaumann A, Batt D, Schlitt HJ, Geissler EK, Stoeltzing O.
Mol Cancer Ther. 2008 Nov;7(11):3509-18.

Intravital microscopy of tumor angiogenesis and regression in the dorsal skin fold chamber: mechanistic insights and preclinical testing of therapeutic strategies.
Koehl GE, Gaumann A, Geissler EK.
Clin Exp Metastasis. 2009;26(4):329-44.

No mutations of FGFR3 in normal urothelium in the vicinity of urothelial carcinoma of the bladder harbouring activating FGFR3 mutations in patients with bladder cancer.
Otto W, Denzinger S, Bertz S, Gaumann A, Wild PJ, Hartmann A, Stoehr R.
Int J Cancer. 2009 May 28. [Epub ahead of print]

[51] Gaumann A, Marx J, Bohl J, Kommoss F, Köhler H, Tews DS:
Advanced Leptomeningeal carcinomatosis and cranial nerve palsy as the only presenting symptom of a clinically inapparent gallbladder carcinoma
Pathol Res Pract, 1999; 195(6): 495-497
IF: 0.729

[52] Gaumann A, Hansen T, Köhler H, Kommoss F, Mann M, Maurer J, Kirkpatrick CJ, Kriegsmann J
The expression of cathepsins in osteoclast-like giant cells of an anaplastic thyroid carcinoma with tracheal perforation
Pathol Res Pract, 2001;197(4):257-62
IF: 1.163

[53] Hansen T, Brockmann H, Gaumann A, Mayet W, Schwarting A, Galle PR, Kriegsmann J:
Fulminanter Verlauf einer diffusen alveolären Hämorrhagie bei systemischem Lupus erythematodes. Ein Fallbericht
Z Rheumatol, 2002;61(2):175-79Z
IF: 0.964

[54] Hansen T, Gaumann A, Ghalibafian M, Höferlin A, Heintz A, Kirkpatrick CJ
Hemangiopericytoma of the thyroid gland combined with Hashimoto’s disease- a case report with emphasis to expression of vascular endothelial growth factor (VEGF) and VEGF receptor type I and II
Virchows Archiv 2004; (445):315-319
IF: 2.227

Encapsulated lipomas of the tongue in benign symmetric lipomatosis.
Ettl T, Gaumann A, Ehrenberg R, Reichert TE, Driemel O.
J Dtsch Dermatol Ges. 2009 May;7(5):441-4. Epub 2009 Jan 19.

[1] Konerding MA, Dzemali O, Gaumann A, Eckhardt VF:
Anatomy of the pelvic floor with special reference to the anal sphincters: cross sectional and microscopic examination on human cadavers. In: Constipation and Anorectal Insufficiency, FALK Symposium, Kluwer Academic Publishers, No.95, 1996,33-39

[2] Konerding MA, Fait E, Gaumann A, Dimitropoulou C, Malkusch W:
The vascularization of experimental and human primary tumors: comparative morphometric and morphologic studies. In: Maragoudakis M. (ed.): Angiogenesis – Models, Modulators and Clinical Applications. Plenum Press, New York-London, 1998, 506-509
…DOWNLOAD
[3] Gaumann A, Petrow PK, Dahm M, Mayer E, Otto M, Kirkpatrick CJ,
Kriegsmann J:
The Expression of Osteopontin in Sarcomas of the Pulmonary Artery
In: Verhandlungsband der deutschen Gesellschaft für Pathologie: Verh. Dtsch. Ges. Path. 82. Gustav Fischer Verlag, Jena, 1998, 405-406

[4] Konerding MA, Fait E, Gaumann A:
3D-Morphometry of the Microvascular Unit in Tumors and Normal Tissues: Quantitative Studies on Microvascular Corrosion Casts
In: J.D. Catravas, A.D. Callow, U.A. Ryan (eds.): Vascular endothelium: Mechanisms of cell signaling. Series A: Life Sciences Vol. 309, IOS Press, Amsterdam, 2000,

[5] Konerding MA, Fait E, Malkusch W, Gaumann A:
3D-morphometry of the microvascular architecture in normal human tissues, precanceroses and primary tumors: Quantitative corrosion cast studies
In: GM Bailey, S McKernan, RL Price, SD Walck, PM Charest, R Gauvin (eds.) Proceedings of Microscopy & Microanalysis 2000, Springer Verlag, New York Heidelberg, 566-567

[6] Gaumann A, Bode-Lesniewska B, Mentzel T
Recent advances in the molecular pathology, diagnosis and treatment of sarcomas of the pulmonary artery, In: Advances in Cancer Research 3rd edition 2002(Vol.2) Part II, Global Research Network Press Kerala, India;353-360

[7] Gaumann A, Groot M, Drexler HC, Breier G
Autocrine stimulation of Receptor-Tyrosine Kinases (RTK) in human tumor cell lines in vitro: therapeutic implications
In: Verhandlungsband der deutschen Gesellschaft für Pathologie: Verh. Dtsch. Ges. Path. 87. Gustav Fischer Verlag, Jena, 2003, 233-239

[8] Gaumann A, Gaumann E, Woenckhaus M, Woenckhaus U
Anatomie, Physiologie und Pathophysiologie des Raynaud Syndroms und akraler Ischämie Syndrome
In: Raynaud Syndrom und Akrale Ischämie Syndrome; Ed. Prof. Dr. U. Müller Ladner, Uni-Med Verlag, Bremen, 2006